A40 is the most common form, while the 42-amino-acidlong fragment, A42, is less abundant and more associated with AD
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Microbial TyrA orthologs containing an acidic 222 residue prefer ADH over PDH activity The amino acid sequence alignment of TyrAs showed that the Asp222 residue, which is conserved across plant TyrA a (Schenck et al., 2017) was also highly conserved in clade I (Figure 2)