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While the standard adult RDA is approximately 2.4 mcg per day (ICMR-NIN, 2024), the demands of pregnancy and breastfeeding raise this further, as the baby draws on maternal stores directly via the placenta and then through breast milk

By modifying the primary sequence of OXM and linking to the constant region of human IgG4, Jung and colleagues demonstrated their peptide HM12525A had a potent and balanced activity at both GLP-1 and glucagon receptors in vitro and led to body weight loss of 30% in DIO mice over 14 days compared to liraglutide treated mice (74)

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The most successful of these was a letter outreach pilot where Hispanic patient enrollment rates improved from 25% to 48%

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