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Ozempic mimics the hormone GLP-1 to improve insulin production and reduce appetite, primarily for type 2 diabetes

Ondansetron may be considered, though patients should be aware of potential side effects including constipation and, rarely, QT interval prolongation

Changes in regional body composition over 8 years in a randomized lifestyle trial: the look AHEAD study

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Receptor trafficking involves the internalisation of the active receptor: Ligand complex towards endocytic compartments, followed by its deactivation/dephosphorylation and recycling back to the cell membrane, leading to its re-sensitisation, or trafficking to lysosomal organelles for its degradation and final signal termination (McGlone et al., 2021)