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Reduced caloric intake on GLP-1 combined with SGLT-2-mediated glucosuria can push the metabolic state toward ketosis even without severe hyperglycemia

In the adapted strain (A 2 78), the expression levels of the hmgR and carRA genes have risen by 2 times and 1.5 times, respectively, compared to the parent strain (W78)

PolmanCHReingoldSCBarkhofFCalabresiPAClanetMCohenJAet al

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Indications / Uses Tirzepatide is used for weight management in adults who are overweight or have obesity and at least one weight-related complication and for managing Type 2 Diabetes by improving blood sugar control

Significant dehydration from vomiting or diarrhoea can potentially lead to kidney problems, so it's important to maintain adequate fluid intake and seek medical advice if you're unable to keep fluids down