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Cell death in these experiments was suppressed by co-treatment with the specific ferroptosis inhibitor ferrostatin-1, confirming that p53 stabilization did not alter the mode of cell death induced by erastin2 (Fig 1C)

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The activation of D14 is initiated by the intact SL molecule, which induces a destabilized conformation in D14 by interfering with the formation of its catalytic triad, rather than by its hydrolysis intermediates or products 24