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This is well documented

Training and nutrition are still the main drivers of body composition change

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There are three key areas for investment in support of GLP-1 adherence and long-term success: 1

GLP-1RA/tesaglitazar does not differ from the pharmacokinetically matched GLP-1RA in GLP-1R signalling, but shows GLP-1R-dependent PPAR-retinoic acid receptor heterodimerization and enhanced improvements of body weight, food intake and glucose metabolism relative to the GLP-1RA or tesaglitazar alone in obese male mice

Vieira IH, Barros LM, Baptista CF, Rodrigues DM, Paiva IM