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Our metabolomics study showed that genetic inhibition of HMG-CoA reductase was negatively correlated with sphingomyelins and phosphatidylcholines, which increase insulin resistance (84) investigated the association of genetic or pharmacological HMG-CoA reductase inhibition in adipose tissue and concluded that high concentrations of simvastatin decreased adipocyte glucose uptake

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These distinct mucin profiles highlight the potential of MUC5AC and MUC5B, and especially their ratio, as biomarkers and therapeutic targets for managing these chronic respiratory diseases (192, 193)

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