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Aconitase inactivation and oxidative stress have been noted in other neuropsychiatric and neurodegenerative disorders with known mitochondrial involvement, including schizophrenia, 50, 51 Huntington's disease 52 and Parkinson's disease
20, 121128 (Curran Associates, Inc., 2008)
Patulin can cause gastrointestinal problems and also organ damage.[ref] Patulin binds to thiol groups found in the intracellular antioxidant glutathione, which then causes oxidative stress, mitochondrial dysfunction, and cell death.[ref] Health effects of mycotoxins: Mold illness symptoms and genetics Exposure to mycotoxins can produce various physical responses depending on the toxin, exposure route, amount, and individual genetic differences
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This protection reduces unnecessary apoptosis a form of programmed cell death that, when excessive, can deplete healthy cells and weaken tissues.16 TUDCA clearly alters bile chemistry under cholestatic stress, but most evidence for its cellular effects still comes from cell and animal studies
