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A: It can reflect increased training capacity, glycogen/water shifts, appetite changes, or lean mass gain rather than pure fat gain

Science 281 , 16831686 ( 1998)

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Notably, this combination exerts additive or synergistic actions by targeting distinct neuroendocrine pathways: cagrilintide modulates homeostatic and hedonic food regulation centers in the hindbrain and hypothalamus, while semaglutide engages central and peripheral GLP-1 pathways to reduce calorie intake and improve glycemic regulation

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