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10.1056/NEJMoa1612917 34 HonigbergM

Diabetologia 38:14251433 Ziegler D, Hanefeld M, Ruhnau KJ, Hasche H, Lobisch M, Schutte K, Kerum G, Malessa R (1999) Treatment of symptomatic diabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN III study)

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In those experiments, pretreatment with the peptide enhanced subsequent responses to growth hormone stimulation, including increased cell viability, elevated proliferating cell nuclear antigen (PCNA) expression, and greater JAK2 phosphorylation activity [5]