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Vegetarians and Vegans : Since vitamin B12 is primarily found in animal products, those following plant-based diets are at increased risk of deficiency
(More information) Low maternal vitamin B 12 status has been associated with an increased risk of neural tube defects (NTD), but it is not known whether vitamin B 12 supplementation could help reduce the risk of NTD
It's whether the experimental design isolates each compound's contribution, controls for confounding variables, and monitors the right endpoints