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In both dogs and mice, rapamycin therapy improves cardiac function and can potentially treat hepatic glycogen storage disease.[4, 24, 25, 3335] Inhibition of mTOR also results in decreased smooth-muscle cell migration and proliferation within coronary arteries, with rapamycin-coated coronary stents significantly reducing arterial stenosis following stent placement.[36] Still, one of the most striking findings is that rapamycin administration has been associated with a significant increase in subject lifespan, a result observed in multiple model organisms, including yeast [37], fruit flies [38], nematodes [39], and mice.[4046] In humans, oral rapamycin is absorbed rapidly with peak concentrations occurring within one to three hours depending on dosing protocol.[47, 48] In the bloodstream, the vast majority of rapamycin is distributed within red blood cells, and co-administration with a high fat meal can increase the oral bioavailability and AUC by up to 35% while decreasing the maximum blood concentration.[49, 50] In dogs, Larson et al

doi: 10.3233/JPD-2011-11023 96 MinogueA

Biochimica Biophysica Acta (BBA) - Proteins Proteomics 1867, 970979

This may mean that you need to take a break from shoulder pressing heavy weights at the gym, or practicing tennis for 2 hours a day