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It plays a pivotal role in energy balance and postprandial metabolism by enhancing glucose-dependent insulin secretion, suppressing glucagon release, delaying gastric emptying, and promoting satiety through central mechanisms [8, 9]

While individual ingredients like berberine have known safety profiles when taken orally, their safety when delivered through skin patches hasnt been established

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Some researchers split the protocol across two vials instead, reconstituting each with 1 mL for a 10 mg/mL concentration and using one vial for the first 2.5 weeks before starting the second