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In a mouse model of diet-induced MASH, treatment with semaglutide resulted in histological improvements in steatosis, inflammation, and fibrosis in liver compared to baseline, which was associated with body weight loss, intermittent periods of reduced food intake, and improvements in relevant biomarkers

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The free tripeptide chelates a single Cu(II) ion through its N-terminal amine, the deprotonated glycyl amide nitrogen and the histidine imidazole, giving the square-planar complex responsible for the deep blue colour of a reconstituted ghkcu solution

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