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Certain retained components of various cell death pathways such as Fas (CD95)/Fas ligand (FasL, CD95L) signaling, caspase-3, caspase-8, or RIPK1/RIPK3 (receptor-interacting serine/threonine-protein kinase 3)/MLKL (mixed lineage kinase domain like pseudokinase) axis can be considered a heritage of the erythroid lineage cells
Exposure to GBB results in the upregulation of a specific microbial gene cluster, gbu (GBB utilizing), which is responsible for the conversion of GBB to TMAand more abundant in people who eat red meat
Together, the data indicate that glucose derived carbon feeds the mitochondrial metabolite pool and suggest the mitochondria as a possible intermediate location for glucose carbons before supplying nuclear-cytosolic acetyl-CoA in DKO cells