the expected effect size is small and the onset is slow - Avoid antidepressants in bipolar depression presenting with subtle increased psychomotor tempo, pressured speech and racing thoughts due to the increased risk of switch and potentially rapid cycling - Consider ETC as a viable option for the treatment of bipolar depression resistant to pharmacological treatment - Never treat with antidepressants without a mood stabiliser - If an antidepressant is added, use mainly SSRIs due to their low switch rate - If an antidepressant is used in maintenance treatment, the occurrence of manic/mixed symptoms should be monitored carefully The above recommendation is consistent with current Danish guidelines for the pharmacological treatment of bipolar disorder [42], which recommend lithium, quetiapine and lamotrigine as first-line agents for bipolar I disorder, current depressive episode, in at least 70% of patients, and for bipolar II disorder, current depressive episode, in at least 60%

Optimize oral hygiene Bacteria are present everywhere in your mouth, such as the tongue, teeth, and gums, which may cause bad breath and affect your oral hygiene
We identified a T2DM cohort of 294,148 participants from the Korean NHIS database from 2009 to 2018 (Fig
Targeting GLP-1, GIP & GCG in Obesity and Type 2 Diabetes Research
Both compounded semaglutide and Ozempic work by activating GLP-1 receptors to reduce appetite and improve blood sugar control, yet they originate from fundamentally different manufacturing pathways
No formal contraindications derive from human data