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But within 12 months of stopping treatment, they regained two-thirds of the weight they had lost, along with a significant reversal of improvements in some cardiometabolic markers, such as those related to diabetes and heart disease

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The FDA has not approved any SGLT2 inhibitor or GLP-1 receptor agonist for type 1 diabetes, but their use in this patient population may continue due to the significant weight management and cardiorenal benefits observed in people with and without type 2 diabetes, they wrote in JAMA