Seek emergency medical care immediately if you experience a rash, itching, swelling of the face or throat, difficulty breathing, or a rapid heartbeat
These medications carry a boxed warning about thyroid C-cell tumors (contraindicated with personal/family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2) and warnings about potential risks including pancreatitis, gallbladder disease, acute kidney injury with dehydration, and worsening diabetic retinopathy with rapid glucose reduction (particularly with semaglutide)
Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis (European Journal of Preventive Cardiology)
very small needles are used
For individuals with existing heart conditions, this aspect of the safety profile will require careful consideration once the medication becomes available
As with other incretin-based therapies, some clients may experience mild gastrointestinal symptoms (nausea, digestive discomfort) typically during the dose-adjustment phase
