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The skin-specific mechanisms of GHK-Cu include stimulation of Type I and Type III procollagen synthesis, increased production of dermatan sulfate and other glycosaminoglycans, activation of the enzyme lysyl oxidase (which cross-links newly formed collagen), reduction of matrix metalloproteinase-1 (MMP-1, collagenase) activity, and anti-inflammatory suppression of TNF-alpha-induced IL-6 secretion

A selective GH secretagogue that activates GH release in vivo

doi: 10.1016/j.cmet.2022.02.010 238 MirjiGWorthABhatSAEl SayedMKannanTGoldmanARet al

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