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For instance, increased phosphorylation of APP -C-terminal fragment (CTF) Tyr682 inhibited the assembly and activity of V-ATPase by binding to the V0a1 subunit, resulting in elevated lysosomal pH and impaired degradation capacity

[2] Falutz, J., et al

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Young people in their 20s have much higher levels than people in their 60s

Finally, membrane lipid composition and more importantly the long polyunsaturated fatty acid (PUFA) is playing a key role in ferroptosis sensitivity

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