Archived from the original on 4 September 2019
Chen K, Meric-Bernstam F, Zhao H, Zhang Q, Ezzeddine N, Tang LY, Qi Y, Mao Y, Chen T, Chong Z, Zhou W, Zheng X, Johnson A, Aldape KD, Routbort MJ, Luthra R, Kopetz S, Davies MA , de Groot J, Moulder S, Vinod R, Farhangfar CJ, Shaw KM, Mendelsohn J, Mills GB, Eterovic AK
found that chronic cadmium exposure inhibited ferroptosis and promoted the proliferation of prostate cancer cell
Mechanistically, taxifolin suppressed LPS-induced activation of the NF-B pathway, as indicated by decreased phosphorylation of NF-B, along with reduced MLCK expression and MLC phosphorylation
Consequently, precise control of ROS production and elimination is needed [5, 6]
The gene, mapping on chromosome 6, has been identified in 2002 in two parallel studies that classified CT2 as the sixth member of the OCT subfamily (Koepsell, 2013)