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For these reasons, many clinical trials have evaluated the efficacy of N -acetylcysteine (NAC) administration, and many are still ongoing (714 studies, 349 completed), as well as the effects of GSH supplementation (162 studies, 100 completed) ( NAC is both a thiol with antioxidant properties and one of the substrates in GSH biosynthesis

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Resveratrol protects against hyperglycemia-induced oxidative damage to mitochondria by activating SIRT1 in rat mesangial cells