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The pivotal STEP 1 trial, published in The New England Journal of Medicine, described the same pattern in its 1,961 randomized adults: nausea and diarrhea were the most common adverse events with semaglutide, and they were "typically transient and mild-to-moderate in severity and subsided with time." Transient is not a promise for any individual, but it is what the aggregate data showed over 68 weeks

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Blood glucose Blood glucose levels were measured on Days 1 and 21 following diabetes induction to assess hyperglycaemia development and the effect of Retatrutide treatment

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Diabet Med 2021;38:e14548.PubMed 255