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10.18632/aging.100905 119 LeeH.-M.KimT

The doctors typically use a narrow needle, making the shots painless and barely noticeable

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It is important to note that, in patients with long-standing diabetes and insufficient insulin secretory capacity, the glucose-lowering efficacy of GLP-1 RA is likely to be reduced as a result of diminished incretin effects, and concomitant basal insulin treatment may be required [53]

A landmark clinical trial of semaglutide, published in 2021, found that participants experienced an average of 15% weight loss over the course of 68 weeks while those on placebo lost 2%

Dunham said semaglutide has also come with cognitive benefits, such as improved focus