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Dose level, dose-escalation speed, baseline body weight, diabetes status, adherence, trial protocol, diet, activity, and side-effect tolerance all affect the observed timeline

You may not be able to get one without the other

To put that into a normal frequency , we could say: For every 100 people taking the medication, we can save two heart attacks over a three-year period

In their discussion section, they really go for the gold: These data, representing the longest clinical trial of the effects of semaglutide versus placebo on weight, establish the safety and durability of semaglutide effects on weight loss and maintenance in a geographically and racially diverse population of adult men and women with overweight and obesity but not diabetes

It included 722 patients with T2DM and baseline HbA1c between 7 and 9.5% randomized to oral semaglutide 14 mg once daily, liraglutide 1.8 mg once daily or placebo (2:2:1)