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SGs are ribonucleoprotein assemblies that incorporate different components depending on the stimuli present (e.g., heat shock, starvation, oxidative stress, etc.) to regulate the post-transcriptional fate of mRNAs (Chen and Liu, 2017

F., Akesson, M., Stephanopoulos, G

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Lipid peroxidation, in particular, compromises the integrity of neuronal membranes, impairing the function of synapses and disrupting communication between neurons

These fatty acids are first generated by lipolysis of triacylglycerol in lipid droplets, by the enzymes adipose triglyceride lipase (ATGL), hormone-sensitive lipase (HSL), and monoacylglycerol lipase (MGL), and then transported to mitochondria and peroxisomes