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Note: Lemonaid Healths parent company, 23andMe, filed for Chapter 11 bankruptcy in March 2025

Niacinamide 4%: This vitamin B3 derivative reduces pigmentation, improves skin texture, and minimises the appearance of pores

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We used version 2 of the Cochrane risk-of-bias tool (ROB 2) to assess the risk of bias, conducted frequentist random-effects network meta-analyses and evaluated confidence in effect estimates utilising the Confidence In Network Meta-Analysis (CINeMA) framework

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Monthly costs may start around $500 for compounded versions, while name-brand options like Wegovy may exceed $1,300 per month