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118 E2 has been demonstrated in numerous studies to alter systems involved in the pathophysiology of depression, including the serotonin and norepinephrine systems, and to considerably alleviate depressive symptoms in animal models

Chronic Diseases: If folate deficiency isnt treated, it can lead to aging and diseases like autoimmune disorders, heart conditions, infections, cancer, and organ failure

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Journal of Molecular Biology

Similarly, cytokines released in the brain can enter the systemic circulation and promote inflammation in the cardiovascular system, increasing the risk of CVDs