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DOI: 10.1001/jamanetworkopen.2024.59490

Materials and methods Participants This cohort is based on data from The Childhood Health, Activity, and Motor Performance School Study Denmark (CHAMPS-Study DK or CHAMPS)a prospective controlled intervention study evaluating health outcomes based on increased physical activity, conducted in the Danish municipality of Svendborg from 2008 to 2015

Importantly, genome sequencing and RNA expression profiling of the tumors collected in this phase II study are planned, in an attempt to further translate pre-clinical mechanistic insights on VitC action to the clinical setting

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These drugs have a long average life and their use in pregnancy is contraindicated in the absence of safety studies