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Blood levels and side effects of these drugs may increase when combined with grapefruit or grapefruit juice

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Mechanistically, GLP-1 receptor agonists may exert vascular protective effects by suppressing inflammation, limiting oxidative stress, and modulating key enzymes involved in extracellular matrix remodeling ( Matrix metalloproteinases, particularly MMP-9, together with their endogenous inhibitors (TIMPs), play central roles in extracellular matrix turnover and structural vascular remodeling ( The reduction in CRP, a recognized marker of aortic stiffness, medial degeneration, and systemic inflammation, further supports the anti-inflammatory profile associated with GLP-1RA therapy

In the STEP-1 clinical trial, non-diabetic patients taking 2.4 mg of semaglutide lost 14.6% of their body weight, compared to 2.4% with placebo