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Nature 379 (6560), 6972

Factors affecting real-world results include dosing adjustments for side effects, adherence challenges, and less intensive lifestyle support than in trials

Researchers found that GLP-1 receptor agonism significantly reduces Cyp2e1 expression in animal models, with reductions of 40-60% observed

This may be the most underappreciated finding in the entire retatrutide dataset

It is also possible that GLP-1 receptors within the brain are activated by circulating GLP-1 produced in the periphery [14]

Recent literature is cited on patients undergoing upper endoscopy with no predictability regarding holding the drug and finding retained gastric contents