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The world of weight management and metabolic health has been transformed by GLP-1 agonists like semaglutide and tirzepatide

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In markets where there is state/PMI reimbursement of GLP-1 treatment for obesity (eg the US), retatrutide is likely to be reserved as a second-line GLP-1 for those who have failed to lose sufficient weight with a cheaper alternative (such as semaglutide or tirzepatide)

These medications decreased: Heart failure hospitalizations by 10-11% according to meta-analyzes including over 60,000 patients 14

The SURMOUNT-5 trial directly compared the two medications and found tirzepatide produced approximately 20 percent weight loss compared to 14 percent for semaglutide

doi: 10.3390/nu11112566 148 YangFRuanYCYangYJWangKLiangSSHanYBet al