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Although the signaling pathways leading to the progression of apoptosis have been extensively characterized, recent studies highlight the regulatory role of changes in the intracellular milieu (permissive apoptotic environment) in the efficient activation of the cell death machinery

Given that aldosterone can exert different effects on sodium and potassium transport in the kidney tubule under differing physiological conditions these differing effects have been termed the aldosterone paradox

The more practical question is whether peptides can complement existing therapies and potentially allow reduction of treatments that cause long-term side effects

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10.1016/j.lfs.2008.01.007 171 YiL.-T.LiuB.-B.JingLiLiuL.LiuQ.GengDiet al (2014)

10.2217/bmm-2017-0109 19 FryeR