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Tirzepatide treatment was associated with a lower incidence of hypoglycemia and did not pose an increased cardiovascular risk

Efficacy-to-tolerability ratio is lower for female rats on GLP1R agonists As a first step to investigate biological mechanisms underlying sex differences in the response to GLP1R agonists, we administered a single dose of semaglutide or tirzepatide in male and female Wistar rats across a wide range of doses (0.0003 mg/kg up to 0.3 mg/kg

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While this approach can be useful, it is not always recommended