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Published 2025-08-20

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In a db/db mouse model of type 2 diabetes, dapagliflozin treatment for 12 weeks inhibited the expression of TGF- , MCP-1, osteopontin and ICAM-1, and thereby inhibited diabetes-induced inflammation in the kidneys (154)

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Excessive adipose tissue can cause a dysregulation of adipocytokines, leading to increased ROS production [23]