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c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

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Osteoblasts, chondrocytes (cartilage-producing cells), and osteocytes all have IGF-1 receptors

Consequently, researchers use it to probe cell growth and differentiation, protein synthesis, and glucose-metabolism pathways in non-clinical models

Chrysant SG, Chrysant GS

Sundd et al., 2019