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However, when senescent cells evade clearance and accumulate chronically, as often occurs with aging or in pathological conditions, their persistent SASP secretion becomes detrimental [55]

In fact, lower IRRs were observed during both the initial (012 months) and late (1324 months) exposed periods compared with pretreatment, a pattern also seen for SGLT-2 and DPP-4 inhibitors, possibly reflecting increased healthcare contact or a healthier lifestyle during treatment

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If excess skin persists after reaching a stable weight, a surgical consultation is the next step

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doi:10.1042/BST20160474