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Additionally, to simulate sepsis caused by polymicrobial infection and assess the impact of GLP-1RAs, the study utilized a cecal content injection method

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Pharmacol Biochem Behav 52 : 169174

Evolution of GLP-1-Based Therapeutics The therapeutic use of GLP-1RAs has evolved significantly, offering various formulations that provide different efficacy, administration routes, and dosing flexibility [19] [20]

These structural modifications increase aggregation and promote non-covalent binding of the albumin, thus inhibiting the DPP-4, which is injected subcutaneously in the form of isotonic fluid

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