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For example, with a genetically determined increase in the level of toxic metabolites associated with impaired mitochondrial oxidation, in which VPA inhibits carnitine biosynthesis by reducing the concentration of alpha-ketoglutarate and can contribute to the development of carnitine deficiency, L-carnitine preparations are the drug of choice for the correction of VPA-induced ADRs

Study Design Details Participants in STEP-1 also received counseling on diet and exercise, with recommendations to reduce daily caloric intake by 500 calories and increase physical activity to 150 minutes per week