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The top obesity medications (OMs) at that time were phentermine, marketed as Adipex-P, and orlistat, marketed as Xenical and Alli

Do not use GLP-1 + GIP treatments if: Warnings and Precautions: Pregnancy and Reproductive Health: GLP-1 + GIP medications may cause harm to a fetus and should not be used during pregnancy or by individuals planning to become pregnant

Liraglutide, injectable semaglutide, and dulaglutide have shown statistically significant reductions in major adverse cardiovascular events in patients with established cardiovascular disease or multiple risk factors

What else can prescribing physicians do (or patients request)

There is no clinical evidence that GLP-1 patches help with diabetes

Extended Data Figure 4 Walkthrough of peptide 5 interactions with GLP-1R StaR