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Interestingly, about one third of people with IBS have anxiety symptoms, suggesting a potential shared gutbrain inflammatory axis between GAD and IBS (Grover et al., 2021)

Excessive production of oxidative stress has been reported to lead to airway inflammation, lung function decline, mucus overproduction, tissue injury, and remodelling in animal models and human studies [14, 15]

If fatigue is a concern, tirzepatide with B12 may be preferable

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Toxicity of nanoparticles in biomedical application: nanotoxicology