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Patients with DS often experience low muscle tone, which is possibly due to decreased acetylcholine levels in the peripheral nervous system

Anything that is severe, worsening, or systemic is a reason to stop and seek a clinician rather than to adjust the protocol

Once the peptide establishes itself as a recurring, non-threatening presence, these defensive reactions typically subside

GI side effects are most frequent and include nausea (25%44%), diarrhea (19%30%), vomiting (8%24%), constipation (17%24%), and abdominal pain (9%20%) [41, 42, 43, 44, 45, 46]

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