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It mostly does, but there are important nuances

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Parenteral thiamine can in rare instances trigger an acute allergic response characterized by hypotension, breathlessness, itching, and swelling

The result is a significant boost in intracellular NAD+ levels, which in turn activates sirtuins (SIRT1) proteins known to regulate cellular health and metabolism

Comment: Commenters indicated that the proposed data collection on Worksheet S-12 would be administratively burdensome and that it was often unclear how the hospital should perform the required calculations