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As with all research compounds, investigators should implement appropriate laboratory safety protocols and follow institutional guidelines for handling investigational chemical compounds in controlled research environments

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Symptoms can be a drop in blood pressure related to vascular permeability and vascular dilatation, and obstruction of airways related to smooth muscle contraction/bronchoconstriction

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Furthermore, combination therapy was associated with a mean 3.22 kg reduction in body weight and did not increase the risk of hypoglycaemia (RR 0.99) versus other therapies

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