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Microb Ecol Health Dis 26(1):25877 Clayton TA, Baker D, Lindon JC, Everett JR, Nicholson JK (2009) Pharmacometabonomic identification of a significant host-microbiome metabolic interaction affecting human drug metabolism

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Several drug-activated nuclear receptors including constitutive androgen receptor (CAR) and pregnane X-receptor (PXR) recognize drug responsive elements within the 5 flanking promoter region of CYP2C genes to mediate the transcriptional up-regulation of these genes in response to xenobiotics and steroids (19)