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These glycemic improvements occur without a corresponding increase in severe hypoglycemia when used as monotherapy, though the risk of hypoglycemia increases when semaglutide is combined with insulin or sulfonylureas

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In healthy adults the total concentration sits around 200 to 600 pmol/L, but the upper reference limit varies by laboratory and by analytical platform

Major Findings: Reviewed the design and rationale of the TRIUMPH and TRANSCEND clinical trial programs

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