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[52] showed that a 12-month treatment with sitagliptin significantly decreased systolic [( 7.0 18.9) mmHg] and diastolic [( 5.1 11.7) mmHg] blood pressure in patients with both T2DM and cardiovascular risk factors

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However, the substantial overall fat reduction means even resistant areas eventually diminish

The study of more than 3,127 adults found that it reduced weight by an average of 27.3 pounds (12.4%) among people who had obesity or overweight with at least one weight-related medical problem such as hypertension, who did not have diabetes, and who were using the highest dose of the medication, the company said in a news release

An important nuance: about three-quarters of the weight lost was fat, while roughly one-quarter was lean mass (muscle, water, bone density)