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Physical Activity and Exercise Engage in regular physical activity, such as brisk walking, strength training, or low-impact cardio, to support weight management and overall metabolic health

doi:10.1016/j.cmet.2019.07.013 337

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Other examples of potential functional interactions might include the receptor for long-chain saturated fatty acids, FFA1, which is also expressed in pancreatic beta cells, where its activation leads to GSIS potentiation via G q transducer pathways (Secor et al., 2021) and enteroendocrine L and K cells, where it contributes to incretin hormone secretion, with FFA1 KO mice exhibiting obesity on a low-fat diet (Lu et al., 2021)

Furthermore, the gut-brain-pancreas axis is connected via the parasympathetic vagus nerve with afferent neurons linking the intestinal mucosa, portal vein and hypothalamus