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Furthermore, our results can be generalised mostly to individuals with type 2 diabetes who are already on metformin-based background therapy, given that drug-naive individuals were recruited only in one study [22]

Enhancing NAD + biosynthesis promotes SIRT1- and SIRT3-catalyzed reactions, improving metabolic disorders such as weight gain, insulin resistance, and dyslipidemia associated with an HFD [171]

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