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Sci Signal 8 , ra27, 10.1126/scisignal.aaa0899 (2015)

This dual action activates regenerative TGF- signaling while blocking fibrotic TGF-1/Smad2/3 pathways, demonstrating context-dependent regulatory sophistication

you just need the right tools and the right team

We revealed the molecular mechanism involved in the leptin-induced transcriptional regulation of carnitine palmitoyl transferase 1b ( Cpt1b ) and long-chain acyl-coenzyme A synthetase 1 ( Acsl1 ) using transfection/reporter assays and chromatin immunoprecipitation

41 Further studies also demonstrated that MLCK activation triggers caveolin-1-dependent endocytosis of occludin to effect structural and functional TJ regulation

[DOI] [PubMed] [Google Scholar] 26.Russjan E., Andrzejewski K., Sulejczak D., Kleczkowska P., Kaczyska K